2023 World Conference on Lung Cancer (Posters)-EP06.04. FLUIDIndia:Liquid "First" Approach is a "Solid" Solution in NSCLC

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A study conducted at the Rajiv Gandhi Cancer Institute and Research Center in India compared the use of liquid biopsy versus tissue biopsy for molecular profiling in patients with non-small cell lung cancer (NSCLC). The study aimed to evaluate the feasibility and accuracy of using liquid biopsy as a first approach in NSCLC patients.<br /><br />The study included 202 NSCLC patients with stage IV adenocarcinoma histology. The results showed that tissue analysis failed in 17.3% of the patients. However, liquid biopsy was able to detect actionable mutations in 28% of the patients.<br /><br />The concordance for actionable drivers between liquid biopsy and tissue biopsy was 61%, while the concordance for single nucleotide variants (SNVs) and insertions and deletions (indels) was 90%. It was noted that liquid biopsy detected ERBB2 alterations in 6 patients that were missed on tissue biopsy. However, the concordance for fusions was only 43%, with 16 out of 18 cases missed on liquid biopsy.<br /><br />The sensitivity of liquid biopsy was found to be 92%, and treatment changes were seen in 17.1% of the patients following liquid biopsy. The turnaround time for liquid biopsy was shorter, with a median of 11.2 days, compared to 23 days for tissue biopsy.<br /><br />The study concluded that liquid biopsy as a first approach in NSCLC patients is a good tool, but efforts are needed to improve the detection of fusions using liquid biopsy. The study is the largest single center concordance study reported in the literature and provides evidence for the advantages of the liquid first approach.<br /><br />In summary, the study highlights the potential of using liquid biopsy as a non-invasive and efficient method for molecular profiling in NSCLC patients. It suggests that liquid biopsy can detect actionable mutations and lead to treatment changes in a significant number of patients. However, further optimization is needed to improve the detection of fusions using liquid biopsy.

Asset Subtitle

Ullas Batra

Meta Tag

Speaker Ullas Batra

Topic Pathology & Biomarkers: Liquid Based Biomarkers

Keywords

liquid biopsy

tissue biopsy

molecular profiling

non-small cell lung cancer

NSCLC

feasibility

accuracy

actionable mutations

concordance

sensitivity